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A further consequence of reduced bile acid flow into the intestine is the decreased activation of FXR and TGR5, which normally play key roles in promoting mucosal immunity and maintaining the intestinal barrier [18] (Figs

However, neuropsychiatric symptoms developing on the basis of direct brain tissue pathology or underlying vascular dysfunction are considered to be a major and the most common feature of long COVID [4, 7, 31, 37, 65, 88, 113], with potentially devastating consequences for affected individuals